THERAPEUTIC PLASMA EXCHANGE · FRANKLIN, TENNESSEE
Reset Your System from the Inside Out: Therapeutic Plasma Exchange (TPE)
Over time, your bloodstream naturally accumulates inflammatory proteins, environmental toxins, and metabolic waste that can slow down your body’s ability to repair and thrive. Therapeutic Plasma Exchange (TPE) is an advanced, minimally invasive outpatient procedure designed to cleanse your internal environment, lower systemic inflammation, and help you feel sharper, lighter, and more energized.
Each TPE session is cumulative with maximum results achieved with six sessions.
Because inflammatory proteins and toxins rebound after an initial exchange, a minimum of two sessions is required to deliver sustained benefits.
01 / WHY PATIENTS SCHEDULE TPE
Why Patients Schedule TPE
While traditional wellness therapies add nutrients to your body, TPE focuses on removing what is holding you back. Patients choose TPE to support:
-
Sharper Mental Clarity and Focus
By clearing neuroinflammatory markers and circulating toxins, TPE helps lift persistent "brain fog" and supports memory and cognitive endurance.
-
Reduced Chronic Inflammation
Lowering inflammatory proteins in the bloodstream relieves systemic stress linked to fatigue, joint discomfort, and sluggish recovery.
-
Deep Cellular Detoxification
TPE physically removes stubborn environmental burdens—such as heavy metals, mycotoxins, and microplastics—that standard detox protocols cannot reach.
-
Longevity and Healthy Aging
Replacing aged plasma creates a cleaner internal environment that supports immune balance, microcirculation, and cellular repair.
-
Renewed Stamina and Vitality
Many patients report noticeable improvements in daily energy levels, sleep quality, and physical resilience within days of treatment.
02 / CONDITIONS
Clinically Proven & Research-Backed Conditions
Originally established in hospital medicine and validated across dozens of medical indications, TPE directly removes the circulating factors driving chronic illness and cellular decline. Our wellness protocols apply this proven technology to support patients dealing with:
-
Autoimmune & Inflammatory Disorders (e.g., Myasthenia Gravis, Guillain-Barré Syndrome, CIDP, Lupus)
In autoimmune conditions, the immune system produces abnormal autoantibodies that mistakenly attack healthy nerves, muscles, and tissues. TPE physically filters these harmful autoantibodies and inflammatory cytokines out of the bloodstream, offering rapid symptom relief and reducing systemic flare-ups.
-
Cognitive Decline & Early Alzheimer’s Disease
Clinical research—including the landmark AMBAR trial—has shown that replacing aged plasma with fresh albumin helps slow cognitive and functional decline. TPE clears neuroinflammatory markers and amyloid-binding proteins from circulation, while fresh albumin acts as a powerful antioxidant that protects brain tissue and improves mental clarity.
Explore the Alzheimer’s research -
Biological Aging & "Inflammaging"
As we age, senescent ("zombie") cells release pro-inflammatory proteins into the plasma that accelerate tissue wear and fatigue. Human clinical trials conducted with the Buck Institute for Research on Aging demonstrate that TPE reduces biological age markers by clearing these age-accelerating factors and restoring a healthier immune cell balance.
-
Severe Hyperlipidemia & Elevated Lipoprotein(a)
For individuals with stubbornly high cholesterol, triglycerides, or genetic Lipoprotein(a) that resist standard lifestyle changes, TPE directly removes excess lipid particles from the blood. This immediate reduction lowers blood viscosity, improves microcirculation, and supports long-term cardiovascular health.
-
Blood & Vascular Disorders (e.g., TTP, Vasculitis)
In conditions where abnormal proteins cause dangerous blood clotting or blood vessel inflammation, TPE is a gold-standard therapy. It simultaneously removes vessel-damaging immune complexes and replenishes healthy, protective plasma proteins.
03 / THE PROCEDURE & YOUR VISIT
How It Works
More than half of your blood is made up of plasma, the liquid carrier that transports nutrients, hormones, and proteins throughout your body. During a TPE session, your blood is gently circulated through a specialized medical device that separates your healthy red and white blood cells from your aged, toxin-heavy plasma. Your healthy blood cells are immediately returned to your body alongside a fresh, pure replacement fluid—typically medical-grade albumin and saline—giving your system a clean slate to function at its peak.
What to Expect During Your Visit
Your comfort and safety are our top priorities. Each outpatient session takes approximately 2 to 3 hours in a calm, relaxing private suite under the continuous supervision of our specialized medical team. There is no surgery and no downtime—you can read, work, or rest comfortably during the exchange and return to your normal routine the very same day.
Ask About TPE04 / THE EXCHANGE
What happens during plasma exchange?
Therapeutic plasma exchange separates plasma from blood cells. Removing plasma can remove circulating antibodies and other proteins. The blood cells are returned with replacement fluid selected for the clinical situation. [1]
Separate
Blood passes through a treatment system that separates plasma from the blood cells.
Exchange
The separated plasma is removed. The clinical plan determines the replacement fluid.
Return
The blood cells return to the body with replacement fluid. The procedure requires clinical monitoring.
A general treatment overview. Your clinician explains the procedure, replacement products and monitoring selected for you. [1, 4]
05 / PUBLISHED RESEARCH
Why TPE is being studied for Alzheimer’s
Researchers have studied plasma exchange with albumin replacement in people with mild-to-moderate Alzheimer’s disease. The studies examine whether this approach can slow changes in everyday function and cognition. [2][3]
The AMBAR study
In the AMBAR randomized trial, the pooled treatment groups had less decline in everyday function than the sham-procedure group at month 14. The main cognitive comparison showed a trend but did not reach conventional statistical significance. [2]
Study design and measured findings
The trial randomized 347 participants. Treatment included six weekly exchanges, followed by monthly low-volume exchanges for 12 months; outcomes were assessed at month 14. The daily-function measure showed 52% less decline versus sham (ADCS-ADL; p=0.03). The cognitive measure showed 66% less decline (ADAS-Cog; p=0.06). These are changes in study scores, not recovery rates or percentages of patients helped. The study was sponsored by Grifols. [2]
Later clinical research
A 2025 study compared 32 treated patients with 194 historical controls and reported less decline on certain cognitive measures. It adds observational evidence, but the historical comparison is not equivalent to a randomized trial. [3]
Read the original publication ↗These studies do not establish a cure, an individual result or the same benefit for other cognitive disorders. Their treatment schedules and results are not automatically the Biologix protocol or Biologix outcomes. [2][3]
Read the original sources
- [1] National Cancer Institute. Plasma exchange.
General procedure definition, not Biologix-specific operating instructions.
- [2] Boada M, et al. AMBAR primary results. Alzheimer’s & Dementia. 2020;16:1412–1425. doi:10.1002/alz.12137.
Randomized, sham-controlled study. Sponsored by Grifols. Research findings are not Biologix outcome data.
- [3] Taragano F, et al. Therapeutic plasma exchange in Alzheimer’s disease. Journal of Alzheimer’s Disease. 2025;108:129–141. doi:10.1177/13872877251375430.
Observational study with historical controls; not a randomized comparison.
- [4] UCLH / National Hospital for Neurology and Neurosurgery. Plasma Exchange Service at NHNN.
General procedure and risk information. Its equipment, schedule and aftercare are not adopted as Biologix’s protocol.
06 / CONNECT WITH BIOLOGIX
Ask about TPE.
Ready to experience a true biological reset? Schedule a one-on-one consultation with our Patient Care team to find out if Therapeutic Plasma Exchange is the right step for your health and longevity goals.
Patient Care
PATIENT & FAMILY GUIDE
Therapeutic Plasma Exchange
A guide to the procedure, research and next step.